2-(3-Chloro-4-fluorophenoxy)ethylaminehydrochloride is an organic compound with the chemical formula C10H13ClFNO.HCl. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White solid
-Melting point: 180-182°C
-Molecular weight: 255.13g/mol
Use:
2-(3-Chloro-4-fluorophenoxy)ethylaminehydrochloride is commonly used as an intermediate in organic synthesis. It can be used to prepare some drugs, pesticides and other compounds with biological activity.
Preparation Method:
The preparation method of 2-(3-Chloro-4-fluorophenoxy)ethylaminehydrochloride is relatively complicated and generally involves a multi-step reaction. One possible synthetic route includes the following steps:
1. Condensation reaction of 3-chloro-4-fluorophenol with dibutyl bicarbonate to obtain 3-chloro-4-fluorophenyl dibutyl carbonate.
2. 3-Chloro-4-fluorophenyl dibutyl carbonate is condensed with 1-bromo-2-bromomethylethane in the presence of a base to give 2-(3-chloro-4-fluorophenoxy) ethane -1-bromomethyl.
3.2-(3-chloro-4-fluorophenoxy) ethane -1-bromomethyl is reacted with ammonia to generate 2-(3-chloro-4-fluorophenoxy) ethane -1-amine.
4. Finally, 2-(3-chloro-4-fluorophenoxy) ethane-l-amine was reacted with hydrochloric acid to give 2-(3-Chloro-4-fluorophenoxy)ethylaminehydrochloride.
Safety Information:
- 2-(3-Chloro-4-fluorophenoxy)ethylaminehydrochloride may irritate the eyes and skin under certain conditions (may cause irritation or allergic reactions), so protective measures should be paid attention to during use.
-It may also be an irritant to the respiratory, digestive and central nervous systems.
-Pay attention to the use of personal protective equipment (such as gloves, protective glasses, masks, etc.) and ensure good ventilation during operation.
-Due to its chemical properties, 2-(3-Chloro-4-fluorophenoxy)ethylaminehydrochloride should be stored in a dry, ventilated and dark place, and away from combustibles and oxidants.